Director CMC Quality Compliance (Hybrid)
Vertex Pharmaceuticals · Boston, MA
- Level
- Director+
- Team
- Quality
- Base pay
- $185k–$277k
- Degree
- Required (or equivalent experience)
- Experience asked
- 10+ years
- Industry
- Pharma & life sciences
- Posted
- Recently
The role in 30 seconds
A director-level quality role at Vertex Pharmaceuticals (pharma & life sciences) in Boston, MA. Provides leadership, development and coaching to staff.
- They ask for
- 10+ years · degree required (or equivalent experience)
- Tools it names
- FDA / GMP, Automation
- Base pay
- $185k–$277k
Read from the posting. The full description is below.
From the plant jobs report · week of October 19, 2026
Quality Engineer roles in Massachusetts: typical posted base $107k–$149k. This one lists $185k–$277k.
Median of the low and high ends of 50 live postings that list pay, out of 70 quality engineer openings in Massachusetts, read from manufacturers' own careers sites.
Massachusetts plant jobs report →Pay by team and state →What moves pay →
How this role compares
Against 69 other live quality postings in Massachusetts.
- Base pay
- About 94% above similar roles
- Experience asked
- More than usual (10+ vs 5+)
Typical $100k–$138k, from 39 postings that list pay.
Similar roles usually ask 5+ years.
Skills these teams ask for most
- Root cause 69%
- ✓ FDA / GMP 60%
- Validation (IQ/OQ/PQ) 51%
- CAPA 50%
- ISO 13485 46%
- FMEA 37%
✓ = this posting asks for it too. % = share of similar postings that mention it.
At a glance
Pulled from the posting text. If it's not listed here, the posting didn't say.
How to get in at this plant
Five moves over a week or two. The first one takes ten minutes.
- 1
Pick 2–3 people on the Quality team at Vertex Pharmaceuticals
We found 3 people at this company and state: 1 in this kind of role, 2 leaders. Engineers who joined in the last year or two reply the most. See them ↓
- 2
Send a short, curious note
One real question about their work. No favors yet. Each person gets a different note, written for this role.
Write to Alexander → (free) - 3
Turn a reply into a short call
Questions worth asking about this team:
- What does a normal week look like on your team?
- Which standards drive the work here: ISO 13485, IATF 16949, AS9100?
- How much of the job is customer complaints versus prevention?
- How did you land the job? What stood out in your interviews?
- 4
Apply with someone vouching for you
If the call went well, ask whether they’d pass your résumé to the hiring manager. Send your résumé link, apply that day, and let them know.
- 5
Bring proof to the interview
One page of before-and-after numbers from projects you led: scrap, OEE, cycle time, cost. Plant managers hire on results.
This plant: Vertex Pharmaceuticals in Boston
16 other open roles at this site · 3 people we found in quality roles at Vertex Pharmaceuticals.
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- Associate Director, GxP Operations Support Manufacturing Systems · Production · Director+
- Director, Package Engineering · Manufacturing · Director+
- Operational Excellence & Business Analytics Associate Director · Lean / CI · Director+
- Senior Director Cell & Genetic Therapies Quality - Personalized Medicine · Quality · Director+
- Associate Director, CMC Quality Compliance and Inspection Readiness (Hybrid) · Quality · Director+
Full description from Vertex PharmaceuticalsAs posted on their careers site.ShowHide
Responsibilities
- ◆Accountable for inspection readiness, inspection management, and compliance programs across all GMP areas including external CMOs and internal manufacturing/testing sites.
- ◆Monitor and interpret cGMP regulatory guidelines and trends in the regulatory space and incorporate into phase appropriate control strategies
- ◆Responsible for overseeing internal and external sites, working with cross-functional teams to identify areas of compliance risk, and implementing action plans to improve the overall compliance and quality culture of the sites.
- ◆Monitors health of the inspection readiness and management system, ensures appropriate escalations, and reports to leadership through established governance structure.
- ◆Works across quality and functional areas to ensure inspection program is scalable and flexible including integration of new modalities into the quality systems as Vertex expands its scope of operations
- ◆Provides technical and strategic support to all areas including other quality groups for compliance and inspection related decisions.
- ◆As a people manager within the organization, provides leadership, development and coaching to staff. Provides enterprise-level thinking and strategy direction to staff and acts as a change agent for improvements.
and experience across multiple GxP areas
- ✓Highly collaborative and effective at building strong enterprise and cross-functional relationships; a strategic change leader who delivers results through influence, partnership, and leadership.
- ✓Ability to evaluate quality matters and make decisions utilizing risk-based approach
- ✓Strong technical knowledge including but not limited to: GMP regulations, inspection management, risk management, and quality governance
- ✓Solid quality culture knowledge and understanding of how to influence and improve overall compliance
- ✓Superb facilitation, Communication, and Coaching/influencing skills with proven ability to lead teams
Education and Experience
- ✓Bachelor's degree in a scientific or allied health field (or equivalent degree)
- ✓Typically requires 10 years of work experience and 3 years of management experience, or the equivalent combination of education and experience
Show full description ↓Show less ↑
Job Description
General Summary
The CMC Quality Compliance Director is responsible for inspection readiness and compliance of internal and external sites including evaluating, improving, and monitoring commercial level quality compliance and quality culture. This position provides technical and strategic leadership for inspection readiness and compliance including processes and associated governance across all GMP areas. This position focuses not just on the “what” but the “how”, ensuring phase appropriate and risk-based compliance.
Knowledge and Skills
- •Expert knowledge of global GMP
Other
- •5-10% Travel may be required
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range
$184,600 - $277,000
Disclosure Statement
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation
Hybrid-Eligible Or On-Site Eligible
In this Hybrid-Eligible role, you can choose to be designated as
1. Hybrid : work remotely up to two days per week; or select
2. On-Site : work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
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